The use of anti-aging drug combinations in life extension investigations: the experience of crowdfunding research.
Iryna Pishel, PhD, D.Sc., Victoria Darchyk, Olga Horobets
D. F. Chebotaryov State Institute of Gerontology NAMS of Ukraine, Kyiv
Today the campaign for the approval of aging as a disease initiated worldwide. And now, anti-aging therapy begins to be developed actively. Development of such anti-aging drug composition is the purpose of this study.
For this study, we used two different approaches. First - we selected 10 well-known drugs that have different mechanisms of action, with the most proven effect on life expectancy; and have used 3 different combinations of these drugs for anti-aging research: combination “A” - Aspirin, Everolimus, Metoprolol Tartrate, Metformin Hydrochloride, Simvastatin, Ramipril; combination “B” - Simvastatin, Hydrochlorothiazide, Losartan Potassium, Amlodipine besylate; and a combination “C” - Aspirin, Everolimus, Metformin Hydrochloride. Second - we began testing the effect of a C60 olive oil (C60OO) solution on the life span of mice.
Preliminary data suggest two main results. First, chronic administration of these drug combinations to mice from the age of 23 months (~ 60-70 years for a man) has led to the opposite effect - the lifespan of mice tended to decrease. This fact might indicate the ineffectiveness of initiation of anti-aging therapy in such a late age. Second, chronic administration of these drug combinations to mice from the age of 16-18 months (~ 50-60 years for a man) has led to the trend of increasing life expectancy. The report discusses the preliminary results of the study.
Iryna Pishel, PhD, D.Sc., Victoria Darchyk, Olga Horobets
D. F. Chebotaryov State Institute of Gerontology NAMS of Ukraine, Kyiv
Today the campaign for the approval of aging as a disease initiated worldwide. And now, anti-aging therapy begins to be developed actively. Development of such anti-aging drug composition is the purpose of this study.
For this study, we used two different approaches. First - we selected 10 well-known drugs that have different mechanisms of action, with the most proven effect on life expectancy; and have used 3 different combinations of these drugs for anti-aging research: combination “A” - Aspirin, Everolimus, Metoprolol Tartrate, Metformin Hydrochloride, Simvastatin, Ramipril; combination “B” - Simvastatin, Hydrochlorothiazide, Losartan Potassium, Amlodipine besylate; and a combination “C” - Aspirin, Everolimus, Metformin Hydrochloride. Second - we began testing the effect of a C60 olive oil (C60OO) solution on the life span of mice.
Preliminary data suggest two main results. First, chronic administration of these drug combinations to mice from the age of 23 months (~ 60-70 years for a man) has led to the opposite effect - the lifespan of mice tended to decrease. This fact might indicate the ineffectiveness of initiation of anti-aging therapy in such a late age. Second, chronic administration of these drug combinations to mice from the age of 16-18 months (~ 50-60 years for a man) has led to the trend of increasing life expectancy. The report discusses the preliminary results of the study.
