DAY 1: Biology of aging is now robust science and it can extend healthy lives
8:00-9:00 Registration
9:00-9:05 Welcome remarks: Sven Bulterijs (Heales vzw)
9:05-9:10 Setting the Stage - Heales: Victor Bjork (Heales vzw)
9:10-9:15 Setting the Stage - Leyden Academy on Vitality and Ageing: Diana Van Heemst (University of Leiden)
1. Introduction to the European Innovation Partnership on Active and Healthy Ageing
9:15-9:35 With a focus on Healthy Ageing, including biology of ageing: Orsolya Nagy (European Commission)
2. General overview of ageing
9:35-9:55 Lessons from the past for the future: the malleability of life expectancy: Edouard Debonneuil (Heales vzw)
9:55-10:15 Political, sociological and cultural impact of a longer and healthier life: Didier Coeurnelle (Heales vzw)
10:15-10:30 Pause
10:30-11:10 Introduction into the biology of ageing: Kyung-Jin Min (Inha University, Korea)
11:10-11:30 Theories of ageing: Diana Van Heemst (Leyden Academy, Netherlands)
3. Molecular damage in ageing
11:30-12:00 Increased damage to proteins in ageing – wear and tear potentially avoidable by extending preventive maintenance of life’s essential machinery: Naila Rabbani (University of Warwick, England)
12:00-13:30 Lunch
13:30-14:00 Alternative Perspectives on Ageing in the Nematode Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?: David Gems (University College London, England)
14:00-14:30 DNA damage as a driver of aging: Martijn Dolle (Rijksinstituut voor Volksgezondheid en Milieu, Netherlands)
4. Mitochondria and autophagy: a promising interaction
14:30-14:50 Mitochondria in ageing: Aubrey de Grey (SENS Foundation)
14:50-15:10 Pause
15:10-15:30 Autophagy and neurodegeneration: David C. Rubinsztein (University of Cambridge, England)
15:30-15:50 The mitochondrial-lysosomal axis of ageing: Alexei Terman (Karolinska University Hospital in Huddinge, Sweden)
15:50-16:00 Pause
5. Panel session
16:00-17:00 Causes, mechanisms, and interventions in ageing
David Gems (University College London, England), Kris Verburgh (University of Antwerp, Belgium), Aubrey de Grey (SENS Foundation, England), Diana Van Heemst (University of Leiden) and Sven Bulterijs (Heales, moderator)
6. Informal meeting
18:00 A La Mort Subite
Collective topic requests (geroprotectors, accumulation of damage, long term health industries, policies..)
Two topics specifically discussed: 1) a European compound-effects-on-health-and-lifespan testing center in mice 2) How to get funding for biology of aging, as it is so low
DAY 2: Concrete examples of research and innovation to extend healthy lives
1. Genetics of Ageing
8:00-8:20 Mitochondria and longevity (Gilad Lehmann, Ben-Gurion University of the Negev)
8:20-8:40 Epigenetics of aging: Mario Fraga (Asturias Central University Hospital, Spain)
2. What can we learn from the oldest old?
8:40-9:00 Lessons from the Blue Zones where people are living longer: Michel Poulain (Université catholique de Louvain, Belgium)
9:00-9:20 The Leiden 85+ study: Rudi Westendorp (University of Leiden, Netherlands)
9:20-9:40 Glucose regulation in the elderly: Diana van Heemst (University of Leiden, Netherlands)
9:40-10:00 Pause
3. Nutritional interventions in ageing
10:00-10:20 Importance of diet in health: Kris Verburgh (Heales vzw)
10:20-10:40 Healthy life extension by calorie restriction: Sven Bulterijs (Heales vzw)
4. Pharmacological interventions in ageing
10:40-11:20 Geroprotectors: Stephen Spindler (University of California Riverside, USA)
11:00-11:20 Metformin in cancer therapy: a new perspective for an old antidiabetic drug: Frederic Bost (INSERM, France)
11:20-11:50 A combination of blood pressure and lipid lowering medication reduces CVD mortality: David Wald (Queen Mary, University of London, England)
12:10-13:40 Lunch
5. Biomedical interventions in ageing
13:40-14:10 Repair of damaged mitochondria by RNA import: Carla Koehler (Harvard University, USA)
14:10-14:30 Destruction of senescent cells: Tobias Wijshake (University Medical Center Groningen, Netherlands)
14:30-14:50 Potential of telomerase in extending health span and longevity in mice: Bruno Miguel Bernardes de Jesus (Spanish National Cancer Research Centre, Spain)
6. Alzheimer's disease
14:50-15:10 Alzheimer's disease: Karolien Bettens (University of Antwerp, Belgium)
15:10-15:30 Pause
7. Regenerative medicine
15:30-15:50 Multipotent adult progenitor cells: Catherine Verfaillie (Catholic University of Leuven, Belgium)
15:50-16:10 Computational support for analyzing induction of pluripotency and other cell
transitions: Georg Fuellen (Institute for Biostatistics and Informatics in Medicine and Ageing Research, Germany)
16:10-16:30 iPS a new source of cells for therapies of ageing and age-related diseases: Alexandra Stolzing (Fraunhofer Institute for Cell Therapy and Immunology, Germany)
8. Panel session
16:30-17:30 Pathways to concrete healthy life extension in the coming decades
Alexandra Stolzing (Fraunhofer Institute for Cell Therapy and Immunology, Germany), Sven Bulterijs (Heales) Kris Verburgh (Heales), and Edouard Debonneuil (moderator)
9. Informal meeting
18:00 A La Mort Subite
DAY 3: Meeting among stakeholders: building the innovations together
1. Lectures
8:00- 8:20 Organisms senescence as a developmental state and not just as a result of stochastic damage: Dmitri Shytikov (Institute of Gerontology NAMS, Ukraine)
8:20-8:40 Anti-aging centers and movements worldwide - a review. Daria Khaltourina (Russian Academy of Sciences, Russia)
8:40-9:00 Crowd-sourcing support for aging data integration: Georg Fuellen (Institute for Biostatistics and Informatics in Medicine and Ageing Research, Germany)
2. Specific topics and collective answers/projects
9:00- 9:20 Organization of groups // informal meeting
9:20- 9:40 Presentations of collective sharings
9:40-10:00 Pause // Poster session
9:40- 10:00 Presentations of collective sharings
10:00-10:20 Refined topic requests
10:20- 10:40 Organization of groups // informal meeting
10:40- 11:00 Collective sharing of specific topics
11:00-11:20 Pause // Poster session
11:20- 11:40 Presentations of collective sharings
11:40- 12:00 Cross border questions
12:00-13:30 Lunch
13:30-13:50 What’s good for our long term health?: Edouard Debonneuil (Heales vzw)
2. Politics
13:50-14:50 Plenary debate - Political positioning of healthy life extension
With: Orsolya Nagy (European Commission), Ilia Stambler (International Longevity Alliance), Didier Coeurnelle (Heales zvw, moderator)
14:50-17:30 Poster session - general meeting - discussions of common projects
