Day 1 (October 1st)
Day Chair: Sven Bulterijs
08:00-09:00 Registration
09:00-09:15 Welcome remarks: Sven Bulterijs (Heales vzw, Belgium)
1. Genetics of Longevity
09:15-09:25 Joao Pedro de Magalhaes (University of Liverpool, UK)
Sequencing the genome of the longest-lived mammal to identify longevity assurance mechanisms
09:25-09:45 Ana Valdes (University of Nottingham, UK)
Omic markers of aging using twin studies
2. Longevity, Genes and the Extracellular Matrix
09:45-10:25 Leslie Roberts (Hopital Dieu, France)
Longevity and Aging, role of genes and extracellular matrix (ECM)
10:25-10:45 Coffee
3. Glycation in Aging
10:45-11:05 Andreas Simm (University Hospital Halle (Saale), Germany)
Protein glycation: between tissue aging and protection against lung tumor formation
11:05-11:25 Sven Bulterijs (Heales vzw, Belgium)
Chemical tools to study AGEing
11:25-11:45 William Bains (MIT, US)
Advanced Glycation End-products as therapeutic targets: prevent, remove or ignore?
11:45-13:15 Lunch
4. Keynote lecture
13:15-14:15 Holly Brown-Borg (University of North Dakota, USA)
Growth hormone and methionine: Are these factors linked to aging and longevity?
5. Senescence
14:15-14:35 Ken Parkinson (Queen Mary, University of London, UK)
The extracellular metabolome of replicative- and irreparable DNA double strand break-induced senescence overlaps with the age-related metabolome of organs in vivo
14:35-14:55 Daniel Muñoz (Centro Nacional de Investigaciones Oncológicas, Spain)
Cellular senescence in tissue remodeling: from physiology to pathology.
14:55-15:15 Coffee
6. Proteostasis
15:15-15:25 Violaine Planté-Bordeneuve (Réseau amylose et DHU A-TVB, France)
The role of aging in transthyretin amyloidosis (ATTR)
15:25-15:45 Janne Johansson (Karolinska Institutet, Sweden)
BRICHOS - a proprotein domain that prevents amyloid fibril toxicity
15:45-16:00 Martin Denzel (Max Planck Institute, Germany)
Activation of an endogenous metabolic pathway extends health- and lifespan
7. Panel session
16:00-17:00 Hallmarks of Ageing
Moderator: Sven Bulterijs
Panel members: Aubrey de Grey, Graham Pawelec, Christian Bar
18:00 Informal meeting
Location: A La Mort Subite (rue Montagne-aux-Herbes Potagères 7, Brussels)
Day 2 (October 2nd)
Day Chair: Peter Wicks
1. Brain Aging
08:30-08:50 Lorenzo Magrassi (University of Pavia, Italy)
Is there a maximum lifespan for neurons?
08:50-09:10 Jennifer Pocock (University College London, UK)
2. Stem Cells and Regenerative Medicine
09:10-09:30 Wolfgang Wagner (RWTH Aachen University Medical School, Germany)
DNA Methylation Changes in Replicative Senescence and Aging
09:30-09:50 Jean-Marc Lemaitre (Institute of Functional Genomics, France)
Exploring strategies for cell rejuvenation and tissues regeneration
09:50-10:10 Coffee
10:10-10:30 Henne Holstege (VU University Medical Center, The Netherlands)
Somatic mutations found in the healthy blood compartment of a 115-year-old woman demonstrate oligoclonal hematopoiesis
10:30-10:50 Jessie van Hoecke (Catholic University of Leuven, Belgium)
The effect of aging on neuroregenerative capacities: insights from the senescent zebrafish
3. Geroprotective drugs
10:50-11:10 Edouard Debonneuil (International Longevity Alliance)
Geroprotectors; of mice and men
11:10-11:30 Liesbet Temmerman (Catholic University of Leuven, Belgium)
Metformin and healthy aging: mitohormesis is good for you
11:30-11:50 Alex Zhavoronkov (In Silico Medicine, inc., US)
The properties of universal and personalized geroprotector regiments
11:50-12:10 Sven Bulterijs (Heales vzw)
The Hallmarks of Aging Score as a method to classify geroprotective drugs
12:10-13:30 Lunch
4. Immunosenescence and Inflammation
13:30-13:50 TBA
13:50-14:15 Graham Pawelec (University of Tübingen, Germany)
Immunity and ageing: causes and effects of immunosenescence in humans
14:15-14:35 Anne Mieke H. Boots (Rijksuniversiteit Groningen, The Netherlands)
Ageing of the human immune system in health and disease
14:35-14:55 Catharina Matheï (Catholic University of Leuven, Belgium)
14:55-15:15 Coffee
6. Hormesis
15:15-15:40 Suresh IS Rattan (Aarhus University, Denmark)
Healthy ageing, hormesis and future lines of investigation
7. TBA
15:40-16:00 TBA
8. Panel session
16:00-17:00 The Most Promising Intervention Strategies in Ageing
Moderator: Edouard Debonneuil (International Longevity Alliance)
Panel members: Joao Pedro de Magalhaes, Aubrey de Grey
18:00 Informal meeting
Location: A La Mort Subite (rue Montagne-aux-Herbes Potagères 7, Brussels)
Day 3 (October 3rd)
Day Chair: Alexander Tietz
10:00 - 10:40 Darya Khaltourina (International Longevity Association)
The longevity organizations in the world: Policy, Academic Research, Social Movement
10:40 - 11:10 David Wood (Catalyst and Futurist)
Approaching rejuvenation - reflections from a philosopher of science and a critical futurist
10:40 - 12:00 Kris Verburgh (Heales VZW, Belgium)
The most promising Intervention strategies in ageing (synthesis)
12:00 - 14:00 Press conference. The future of ageing and longevity: is the sky the limit?
- Philippe Busquin (former European Commissioner in charge of Research)
- Didier Coeurnelle (co-chair of Heales)
14:30 - 16:30 Working groups on the future of longevity
- Communication and longevity (chaired by Martine Verhaege de Naeyer, press officer of Heales VZW)
- Fundraising and longevity (chaired by Edouard Debonneuil, co-chair of Heales VZW)
- Resilient longevity organisations (chaired by Peter Wicks, Heales VZW)
16:30 - 17:00 Rapports and proposals from the working groups
17:30 Cloture Speech and Goodbye Drink
