Day 1 (Thursday, September 29)
09:30 - 09:45 Welcome remarks: Sven Bulterijs (Heales vzw, Belgium)
09:45 - 10:05 Giuseppe Passarino (University of Calabria, Italy)
Epigenetics and ageing. Correlations with demographic and genetic data.
10:05 - 10:25 David Melzer (University of Exeter, UK and University of Connecticut, USA)
Parental longevity and the multiple protective factor model of human ageing
10:25 - 10:45 Coffee pause and networking
10:45 - 11:05 Helen Birch (University College London, UK)
Advanced glycation end-product crosslinking in ageing skeletal tissues
11:05 - 11:25 Sylvie Ricard-Blum (University Lyon 1, France)
An integrative view of extracellular matrix ageing
11:25 - 11:45 Casper Schalkwijk (Maastricht University, The Netherlands)
Advanced glycation endproducts and vascular AGEing
11:45 - 13:15 Lunch
13:15 - 14:15 Keynote - Alexander Seifalian (University College London, UK)
Is nanotechnology and stem cells a solution for treatment and replacement of damaged organs?
14:15 - 14:35 Philippe Gillery (University of Reims Champagne-Ardenne, France)
Protein carbamylation: hallmark of ageing
14:35 - 14:55 Ivan Bautmans (Vrije Universiteit Brussel, Belgium)
The effects and dose-response relationships of resistance training on circulating BDNF and inflammatory cytokines in older persons
14:55 - 15:15 Coffee pause and networking
15:15 - 15:35 Claudio Franceschi (University of Bologna, Italy)
Signatures of longevity and biomarkers of biological versus chronological age
15:35 - 15:55 Florian Kronenberg (Medical University of Innsbruck, Austria)
Human genetics and the causal role of lipoprotein(a) for cardiovascular disease
16:00 - 17:00 Panel session: The ageing biotech industry
Panel members: Dmitry Kaminskiy, Michael Greve
Moderator: Sven Bulterijs
19.00 - 22.00 Informal meeting: Café A La Mort Subite (second floor), rue Montagne-aux-Herbes Potagères 7
Day 2 (Friday, September 30)
09:20 - 09:40 Rosie Freer (University of Cambridge, UK)
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease
09:40 - 10:00 Salvador Ventura (Universitat Autònoma de Barcelona, Spain)
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis
10:00 - 10:10 Miriam Ji Sun Leis (International Longevity Alliance and International Society on Aging and Disease)
Goals for the life extension community: Advancing LE R&D and awareness on the topic.
10:10 - 10:20 Iryna Pishel (D. F. Chebotaryov State Institute of Gerontology NAMS of Ukraine, Ukraine)
The use of anti-ageing drug combinations in life extension investigations: the experience of crowdfunding research
10:20 - 10:40 Alberto Sanz (Newcastle University, UK)
In vivo regulation of mitochondrial ROS levels as a strategy to extend lifespan
10:40 - 11:00 Coffee pause and Group Picture
11:00 - 11:20 Alexandra Stolzing (Leipzig University, Germany and Loughborough University, UK)
Ageing as modulator and target of cell based therapies
11:20 - 11:40 Masashi Narita (University of Cambridge, UK)
Cell-cell communication in senescence
11:40 - 12:00 Anton Kulaga
Introduction to Kappa, a rule-based language for modeling protein-protein and gene-protein networks based on the DNA repair model
12:00 - 12:20 Quentin Vanhaelen (Insilico Medicine)
Using deep neural networks trained on massive multi-modal inputs for ageing research
12:20 - 13:30 Lunch
13:30 - 14:30 Keynote - David Gems (University College London, UK)
New discoveries about ageing in C. elegans
14:30 - 14:50 Gorlé Nina (VIB Ghent University, Belgium)
The role of type I IFN signaling at the choroid plexus during ageing
14:50 - 15:10 Coffee pause and networking
15:10 - 15:30 Jan Hoeijmakers (Erasmus Medical Center, The Netherlands)
The impact of DNA damage and repair on ageing and sustained health
15:30 - 15:50 Patrizia d’Alessio (Biopark Cancer Campus 1, France)
Biofilm and its implication in aging via « cold inflammation »
16:00 - 17:00 Panel session: Geroprotective interventions: from bench to bedside
Panel members: Edouard Debonneuil, Dmitry Kaminskiy, Miriam Leis
Moderator: Sven Bulterijs
19.00 - 22.00 Informal meeting: Café A La Mort Subite (second floor), rue Montagne-aux-Herbes Potagères 7
Day 3 (Saturday, October 1)
09:20 - 10:00 David Wood (Delta Wisdom, UK and London Futurists, UK)
Scenarios for the future of healthy life extension
10:00 - 10:20 Victor Bjork (Heales vzw)
Supercentenarians and the immunobiome
10:20 - 10:40 Marc Roux (Association Française Transhumaniste – Technoprog, France and Institute for Ethics and Emerging Technologies, US)
A world with less senescence and fewer children
10:40 - 11:00 Coffee pause and networking
11:00 - 11:20 Didier Coeurnelle (Heales vzw)
Longevity and artificial Intelligence
11:20 - 11:40 Sven Bulterijs (Heales vzw and Aging Analytics inc.)
The ageing biotech market
11:40 - 11:50 Robert James Powles (BGRF, UK and Longevity Reporter, UK)
How can we persuade and educate the wider public about the importance of ageing research?
11:50 - 12:00 Arthur Helfstein (Major Mouse Testing Program Gold sponsor of Longevity; IERFH)
Effective Altruist and Existential Risk
12:00 - 12:20 Daria Khaltourina (International Longevity Alliance; Council for Public Health and the Problems of Demography, Russia and Ministry of Healthcare of the Russian Federation, Russia) and Matveyev Yu (Council for Public Health and the Problems of Demography, Russia)
Ageing and International Classification of Diseases
12:20 - 14:00 Press lunch. International Day of Longevity
Ageing in Belgium. What can we do?
14:00 - 15:00 Panel session: Biological ageing: a disease or not?
Panel members: Daria Khaltourina, Victor Björk, Didier Coeurnelle, Robert James Powles
Moderator: Peter Wicks
15:00 - 15:40 General discussion and adoption of a Declaration For Longevity
Moderator David Wood
15:40 - 16:00 Didier Coeurnelle (Heales vzw, Belgium)
Closing ceremony
_____________________________________________________
17.00 - 19.00 Debriefing meeting in the Café A La Mort Subite (second floor), rue Montagne-aux-Herbes Potagères 7 (organized by Heales, EHA participants are welcome)
09:30 - 09:45 Welcome remarks: Sven Bulterijs (Heales vzw, Belgium)
09:45 - 10:05 Giuseppe Passarino (University of Calabria, Italy)
Epigenetics and ageing. Correlations with demographic and genetic data.
10:05 - 10:25 David Melzer (University of Exeter, UK and University of Connecticut, USA)
Parental longevity and the multiple protective factor model of human ageing
10:25 - 10:45 Coffee pause and networking
10:45 - 11:05 Helen Birch (University College London, UK)
Advanced glycation end-product crosslinking in ageing skeletal tissues
11:05 - 11:25 Sylvie Ricard-Blum (University Lyon 1, France)
An integrative view of extracellular matrix ageing
11:25 - 11:45 Casper Schalkwijk (Maastricht University, The Netherlands)
Advanced glycation endproducts and vascular AGEing
11:45 - 13:15 Lunch
13:15 - 14:15 Keynote - Alexander Seifalian (University College London, UK)
Is nanotechnology and stem cells a solution for treatment and replacement of damaged organs?
14:15 - 14:35 Philippe Gillery (University of Reims Champagne-Ardenne, France)
Protein carbamylation: hallmark of ageing
14:35 - 14:55 Ivan Bautmans (Vrije Universiteit Brussel, Belgium)
The effects and dose-response relationships of resistance training on circulating BDNF and inflammatory cytokines in older persons
14:55 - 15:15 Coffee pause and networking
15:15 - 15:35 Claudio Franceschi (University of Bologna, Italy)
Signatures of longevity and biomarkers of biological versus chronological age
15:35 - 15:55 Florian Kronenberg (Medical University of Innsbruck, Austria)
Human genetics and the causal role of lipoprotein(a) for cardiovascular disease
16:00 - 17:00 Panel session: The ageing biotech industry
Panel members: Dmitry Kaminskiy, Michael Greve
Moderator: Sven Bulterijs
19.00 - 22.00 Informal meeting: Café A La Mort Subite (second floor), rue Montagne-aux-Herbes Potagères 7
Day 2 (Friday, September 30)
09:20 - 09:40 Rosie Freer (University of Cambridge, UK)
A protein homeostasis signature in healthy brains recapitulates tissue vulnerability to Alzheimer’s disease
09:40 - 10:00 Salvador Ventura (Universitat Autònoma de Barcelona, Spain)
Repositioning tolcapone as a potent inhibitor of transthyretin amyloidogenesis
10:00 - 10:10 Miriam Ji Sun Leis (International Longevity Alliance and International Society on Aging and Disease)
Goals for the life extension community: Advancing LE R&D and awareness on the topic.
10:10 - 10:20 Iryna Pishel (D. F. Chebotaryov State Institute of Gerontology NAMS of Ukraine, Ukraine)
The use of anti-ageing drug combinations in life extension investigations: the experience of crowdfunding research
10:20 - 10:40 Alberto Sanz (Newcastle University, UK)
In vivo regulation of mitochondrial ROS levels as a strategy to extend lifespan
10:40 - 11:00 Coffee pause and Group Picture
11:00 - 11:20 Alexandra Stolzing (Leipzig University, Germany and Loughborough University, UK)
Ageing as modulator and target of cell based therapies
11:20 - 11:40 Masashi Narita (University of Cambridge, UK)
Cell-cell communication in senescence
11:40 - 12:00 Anton Kulaga
Introduction to Kappa, a rule-based language for modeling protein-protein and gene-protein networks based on the DNA repair model
12:00 - 12:20 Quentin Vanhaelen (Insilico Medicine)
Using deep neural networks trained on massive multi-modal inputs for ageing research
12:20 - 13:30 Lunch
13:30 - 14:30 Keynote - David Gems (University College London, UK)
New discoveries about ageing in C. elegans
14:30 - 14:50 Gorlé Nina (VIB Ghent University, Belgium)
The role of type I IFN signaling at the choroid plexus during ageing
14:50 - 15:10 Coffee pause and networking
15:10 - 15:30 Jan Hoeijmakers (Erasmus Medical Center, The Netherlands)
The impact of DNA damage and repair on ageing and sustained health
15:30 - 15:50 Patrizia d’Alessio (Biopark Cancer Campus 1, France)
Biofilm and its implication in aging via « cold inflammation »
16:00 - 17:00 Panel session: Geroprotective interventions: from bench to bedside
Panel members: Edouard Debonneuil, Dmitry Kaminskiy, Miriam Leis
Moderator: Sven Bulterijs
19.00 - 22.00 Informal meeting: Café A La Mort Subite (second floor), rue Montagne-aux-Herbes Potagères 7
Day 3 (Saturday, October 1)
09:20 - 10:00 David Wood (Delta Wisdom, UK and London Futurists, UK)
Scenarios for the future of healthy life extension
10:00 - 10:20 Victor Bjork (Heales vzw)
Supercentenarians and the immunobiome
10:20 - 10:40 Marc Roux (Association Française Transhumaniste – Technoprog, France and Institute for Ethics and Emerging Technologies, US)
A world with less senescence and fewer children
10:40 - 11:00 Coffee pause and networking
11:00 - 11:20 Didier Coeurnelle (Heales vzw)
Longevity and artificial Intelligence
11:20 - 11:40 Sven Bulterijs (Heales vzw and Aging Analytics inc.)
The ageing biotech market
11:40 - 11:50 Robert James Powles (BGRF, UK and Longevity Reporter, UK)
How can we persuade and educate the wider public about the importance of ageing research?
11:50 - 12:00 Arthur Helfstein (Major Mouse Testing Program Gold sponsor of Longevity; IERFH)
Effective Altruist and Existential Risk
12:00 - 12:20 Daria Khaltourina (International Longevity Alliance; Council for Public Health and the Problems of Demography, Russia and Ministry of Healthcare of the Russian Federation, Russia) and Matveyev Yu (Council for Public Health and the Problems of Demography, Russia)
Ageing and International Classification of Diseases
12:20 - 14:00 Press lunch. International Day of Longevity
Ageing in Belgium. What can we do?
14:00 - 15:00 Panel session: Biological ageing: a disease or not?
Panel members: Daria Khaltourina, Victor Björk, Didier Coeurnelle, Robert James Powles
Moderator: Peter Wicks
15:00 - 15:40 General discussion and adoption of a Declaration For Longevity
Moderator David Wood
15:40 - 16:00 Didier Coeurnelle (Heales vzw, Belgium)
Closing ceremony
_____________________________________________________
17.00 - 19.00 Debriefing meeting in the Café A La Mort Subite (second floor), rue Montagne-aux-Herbes Potagères 7 (organized by Heales, EHA participants are welcome)
