Prospects of practically shattering the ceiling of human longevity
Victor Björk
Heales vzw
Maximum human lifespan remains flat at 115 years, While there is still no consensus for what possible makes people attain this age the data is solid that no progress occurs naturally on this barrier. Out of over 2000 validated people who have reached the age of 110 98% will be dead within 5 years. Among this group of very frail elderly TTR amyloidosis and infections secondary to immunosenescence are leading primary causes of death. This offers us an opportunity to be able to rapidly assess efficacy of interventions into fundamental mechanisms on aging, without having to wait for the proof-of-principle. Unravelling so far unanswered questions into the biology of the oldest old are paramount to be able to design therapeutics that can break lifespan records.
Heales vzw
Maximum human lifespan remains flat at 115 years, While there is still no consensus for what possible makes people attain this age the data is solid that no progress occurs naturally on this barrier. Out of over 2000 validated people who have reached the age of 110 98% will be dead within 5 years. Among this group of very frail elderly TTR amyloidosis and infections secondary to immunosenescence are leading primary causes of death. This offers us an opportunity to be able to rapidly assess efficacy of interventions into fundamental mechanisms on aging, without having to wait for the proof-of-principle. Unravelling so far unanswered questions into the biology of the oldest old are paramount to be able to design therapeutics that can break lifespan records.
