Signatures of longevity and biomarkers of biological versus chronological age
Claudio Franceschi
University of Bologna and IRCCS Institute of Neurological Sciences of Bologna, Italy
I’ll present the last data produced in my laboratory on the genetics, epigenetics and N-glycomics of centenarians (100+), semi-supercentenarians (105+) and their offspring. I’ll describe new loci correlated with human longevity paying particular attention to population genetics and data on an the epigenetic signature of 105+ and their decelerated rate of aging. A particular attention will be devoted to mechanisms underpinning the lifelong changes of DNA methylation of ELOVL2, a top epigenetic biomarker of aging. Data showing that 100+ and 105+ are apparently younger than their chronological age according to the analysis on plasma N-glycans will also be presented and discussed. Finally I’ll present data on the lifelong trajectory and remodeling of human microbiome in subjects from 20 to 109 years of age. All these data are pieces of a puzzle we are trying to reconstruct within the perspective of a systems biology of aging and longevity.
Claudio Franceschi
University of Bologna and IRCCS Institute of Neurological Sciences of Bologna, Italy
I’ll present the last data produced in my laboratory on the genetics, epigenetics and N-glycomics of centenarians (100+), semi-supercentenarians (105+) and their offspring. I’ll describe new loci correlated with human longevity paying particular attention to population genetics and data on an the epigenetic signature of 105+ and their decelerated rate of aging. A particular attention will be devoted to mechanisms underpinning the lifelong changes of DNA methylation of ELOVL2, a top epigenetic biomarker of aging. Data showing that 100+ and 105+ are apparently younger than their chronological age according to the analysis on plasma N-glycans will also be presented and discussed. Finally I’ll present data on the lifelong trajectory and remodeling of human microbiome in subjects from 20 to 109 years of age. All these data are pieces of a puzzle we are trying to reconstruct within the perspective of a systems biology of aging and longevity.
