The effects and dose-response relationships of resistance training on circulating BDNF and inflammatory cytokines in older persons.
Ivan Bautmans¹ ² ³
1 Gerontology department, Vrije Universiteit Brussel (VUB), Brussels, Belgium
2 Frailty in Ageing research department, Vrije Universiteit Brussel (VUB), Brussels, Belgium
3 Geriatrics department, Universitair Ziekenhuis Brussel, Brussels, Belgium
[email protected]
Introduction
Ageing is associated with a chronic low-grade inflammation, which could be counteracted with physical exercise by influencing circulating inflammatory mediators and neurotrophic growth factors.
Methods
In 4 intervention studies including 243 elderly individuals we assessed the effects and dose-response relationships of resistance training (RT) on circulating BDNF and inflammatory cytokines (IL-6, IL-1beta, L-1ra, sTNFR1, IL-8, GM-CSF, IL-10):
1) n=31 aged 68±5 yrs, 6 weeks RT (3x10 repetitions @ 80% 1RM),
2) n=40 aged 67±7 yrs, 12 weeks RT (3x10 repetitions @ 80% 1RM) compared to matched controls,
3) n=56 aged 68±5 yrs, 12 weeks HIGH (2x10-15 repetitions @ 80%1RM), LOW (1x80-100 repetitions @ 20%1RM), or LOW+ (1x60 repetitions @ 20%1RM followed by 1x10-20 repetitions @ 40%1RM), followed by 24 weeks detraining,
4) n=116 aged 71±5 yrs, 12 weeks IST (3x10 repetitions @ 80%1RM), SET (2x30 repetitions at 40%1RM) or FT (4x60seconds muscle stretching),
Results
We observed significant RT-induced effects on inflammatory markers and BDNF in a dose-dependent and gender-specific manner. After 24 weeks detraining, effects on BDNF returned back to baseline.
Conclusion
6-12 weeks RT has considerable neurotrophic and anti-inflammatory effects in older persons. We suggest that exercising until volitional fatigue is the main trigger for exercise-induced responses. Continuous exercise adherence seems to be needed to sustain the training-induced effects on BDNF in older persons.
COI
None
Ivan Bautmans¹ ² ³
1 Gerontology department, Vrije Universiteit Brussel (VUB), Brussels, Belgium
2 Frailty in Ageing research department, Vrije Universiteit Brussel (VUB), Brussels, Belgium
3 Geriatrics department, Universitair Ziekenhuis Brussel, Brussels, Belgium
[email protected]
Introduction
Ageing is associated with a chronic low-grade inflammation, which could be counteracted with physical exercise by influencing circulating inflammatory mediators and neurotrophic growth factors.
Methods
In 4 intervention studies including 243 elderly individuals we assessed the effects and dose-response relationships of resistance training (RT) on circulating BDNF and inflammatory cytokines (IL-6, IL-1beta, L-1ra, sTNFR1, IL-8, GM-CSF, IL-10):
1) n=31 aged 68±5 yrs, 6 weeks RT (3x10 repetitions @ 80% 1RM),
2) n=40 aged 67±7 yrs, 12 weeks RT (3x10 repetitions @ 80% 1RM) compared to matched controls,
3) n=56 aged 68±5 yrs, 12 weeks HIGH (2x10-15 repetitions @ 80%1RM), LOW (1x80-100 repetitions @ 20%1RM), or LOW+ (1x60 repetitions @ 20%1RM followed by 1x10-20 repetitions @ 40%1RM), followed by 24 weeks detraining,
4) n=116 aged 71±5 yrs, 12 weeks IST (3x10 repetitions @ 80%1RM), SET (2x30 repetitions at 40%1RM) or FT (4x60seconds muscle stretching),
Results
We observed significant RT-induced effects on inflammatory markers and BDNF in a dose-dependent and gender-specific manner. After 24 weeks detraining, effects on BDNF returned back to baseline.
Conclusion
6-12 weeks RT has considerable neurotrophic and anti-inflammatory effects in older persons. We suggest that exercising until volitional fatigue is the main trigger for exercise-induced responses. Continuous exercise adherence seems to be needed to sustain the training-induced effects on BDNF in older persons.
COI
None
