The role of type I IFN signaling at the choroid plexus during ageing
Gorlé Nina¹, Balusu Sriram¹, Van Wonterghem Elien¹, Van Imschoot Griet¹, Hoeijmakers Jan², Libert Claude¹, Vandenbroucke Roosmarijn¹
1: Inflammation Research Center, VIB Ghent University
2: Molecular Genetics, Erasmus Medical Center, Rotterdam.
The blood-cerebrospinal fluid (CSF) barrier is formed by choroid plexus epithelial epithelium, a unique single cell layer at the interface between blood and the CSF containing ventricular cavities. Malfunctioning of the blood-CSF barrier can cause serious damage to the CNS. Aging is a complex, multifactorial process, characterized by progressive loss of physiological integrity and associated with several morphological changes at the choroid plexus epithelium. Here, we studied the role of the type I interferon signaling in the age-associated morphological changes at the blood-CSF barrier.
Financial interest disclosure: none to declare.
Gorlé Nina¹, Balusu Sriram¹, Van Wonterghem Elien¹, Van Imschoot Griet¹, Hoeijmakers Jan², Libert Claude¹, Vandenbroucke Roosmarijn¹
1: Inflammation Research Center, VIB Ghent University
2: Molecular Genetics, Erasmus Medical Center, Rotterdam.
The blood-cerebrospinal fluid (CSF) barrier is formed by choroid plexus epithelial epithelium, a unique single cell layer at the interface between blood and the CSF containing ventricular cavities. Malfunctioning of the blood-CSF barrier can cause serious damage to the CNS. Aging is a complex, multifactorial process, characterized by progressive loss of physiological integrity and associated with several morphological changes at the choroid plexus epithelium. Here, we studied the role of the type I interferon signaling in the age-associated morphological changes at the blood-CSF barrier.
Financial interest disclosure: none to declare.
